Current Pharmaceutical Design

William A. Banks  
VAPSHCS/GRECC S-182
Building 1, Room 810A
1600 S. Columbian Way
Seattle, WA 98108
USA

Back

Apolipoprotein E Knockout Models

Author(s): Genovefa Kolovou, Katherine Anagnostopoulou, Dimitri P. Mikhailidis, Dennis V. Cokkinos.

Abstract:

Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time. The current review considers lipid metabolism and inflammation as well as nutritional and pharmacological agents affecting atherosclerosis, using the apo E knock out mouse model.

Keywords: Apolipoprotein E, knock out, atherosclerosis

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 14
ISSUE: 4
Year: 2008
Page: [338 - 351]
Pages: 14
DOI: 10.2174/138161208783497769
Price: $58