Abstract
In the last 50 years, several experimental models of abdominal aortic aneurysms (AAAs) have been described. These models have aided scientists and physicians to understand the pathophysiological mechanisms underlying AAA development and progression. In addition, they have served as means for the development of a number of conservative (such as doxyxycline, marimastat and propranolol) and surgical treatment options for the management of AAAs. In the last few years, experimental models have contributed in the development of novel endovascular techniques for the treatment of AAAs. Animal models of endovascular grafts and percutaneous techniques comprise an essential step for the successful clinical application of these procedures. Additionally, they may comprise part of the training process for vascular surgeons. The different experimental AAA models are briefly presented and their clinical significance is discussed. Experimental models play an essential role in the field of research for the development of more successful therapeutic alternatives for the management of AAAs.
Keywords: Abdominal aortic aneurysms, animal models, experimental, endovascular
Current Pharmaceutical Design
Title: Experimental Models of Abdominal Aortic Aneurysms: An Overview
Volume: 14 Issue: 4
Author(s): Dimitri P. Mikhailidis, Kosmas I. Paraskevas and Despina Perrea
Affiliation:
Keywords: Abdominal aortic aneurysms, animal models, experimental, endovascular
Abstract: In the last 50 years, several experimental models of abdominal aortic aneurysms (AAAs) have been described. These models have aided scientists and physicians to understand the pathophysiological mechanisms underlying AAA development and progression. In addition, they have served as means for the development of a number of conservative (such as doxyxycline, marimastat and propranolol) and surgical treatment options for the management of AAAs. In the last few years, experimental models have contributed in the development of novel endovascular techniques for the treatment of AAAs. Animal models of endovascular grafts and percutaneous techniques comprise an essential step for the successful clinical application of these procedures. Additionally, they may comprise part of the training process for vascular surgeons. The different experimental AAA models are briefly presented and their clinical significance is discussed. Experimental models play an essential role in the field of research for the development of more successful therapeutic alternatives for the management of AAAs.
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Cite this article as:
Mikhailidis P. Dimitri, Paraskevas I. Kosmas and Perrea Despina, Experimental Models of Abdominal Aortic Aneurysms: An Overview, Current Pharmaceutical Design 2008; 14 (4) . https://dx.doi.org/10.2174/138161208783497697
DOI https://dx.doi.org/10.2174/138161208783497697 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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