The Antioxidant Response as a Drug Target in Diabetic Neuropathy

Author(s): Andrea M. Vincent, James L. Edwards, Mahdieh Sadidi, Eva L. Feldman.

Journal Name: Current Drug Targets

Volume 9 , Issue 1 , 2008

Become EABM
Become Reviewer


While increasing antioxidant potential is an attractive treatment strategy for diabetic neuropathy, many years of trials using high-dose oral antioxidants have not produced therapeutic results. An increasing understanding of the innate antioxidant response and the pharmacological agents that can regulate this mechanism may open new avenue for drug development. This review describes the current state of antioxidant trials and the potential for targeting the antioxidant response. In combination with antihyperglycemic agents, agents that regulate the antioxidant response may afford superior protection against cellular oxidative injury in diabetes.

Keywords: dorsal root ganglia, Nrf2 protein, hyperglycemia, oxidative stress, advanced glycation products

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2008
Page: [94 - 100]
Pages: 7
DOI: 10.2174/138945008783431754

Article Metrics

PDF: 14