Correlating Low-Similarity Peptide Sequences and Allergenic Epitopes

Author(s): D. Kanduc .

Journal Name: Current Pharmaceutical Design

Volume 14 , Issue 3 , 2008

Abstract:

Although a high number of allergenic peptide epitopes has been experimentally identified and defined, the molecular basis and the precise mechanisms underlying peptide allergenicity are unknown. This issue was analyzed exploring the relationship between peptide allergenicity and sequence similarity to the human proteome. The structured analysis of the data reported in literature put into evidence that the most part of IgE-binding epitopes are (or harbor) pentapeptide unit(s) with no/low similarity to the human proteome, this way suggesting that no or low sequence similarity to the host proteome might represent a minimum common denominator identifying allergenic peptides. The present literature analysis might be of relevance in devising and designing short amino acid modules to be used for blocking pathogenic IgE.

Keywords: IgE-binding peptides, similarity level, sequence uniqueness, proteomic scanning

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2008
Page: [289 - 295]
Pages: 7
DOI: 10.2174/138161208783413257
Price: $58

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