Patterns of Insertion and Deletion in Mammalian Genomes

Shiheng      Tao; Yanhui      Fan; Wenjuan      Wang; Guoji      Ma; Lijing      Liang; Qi      Shi

Abstract

Nucleotide insertions and deletions (indels) are responsible for gaps in the sequence alignments. Indel is one of the major sources of evolutionary change at the molecular level. We have examined the patterns of insertions and deletions in the 19 mammalian genomes, and found that deletion events are more common than insertions in the mammalian genomes. Both the number of insertions and deletions decrease rapidly when the gap length increases and single nucleotide indel is the most frequent in all indel events. The frequencies of both insertions and deletions can be described well by power law.

Keywords: Insertion, deletion, gap, indel, mammalian genome

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Current Genomics

Title: Patterns of Insertion and Deletion in Mammalian Genomes

Volume: 8 Issue: 6

Author(s): Shiheng Tao, Yanhui Fan, Wenjuan Wang, Guoji Ma, Lijing Liang and Qi Shi

Affiliation:

Keywords: Insertion, deletion, gap, indel, mammalian genome

Abstract: Nucleotide insertions and deletions (indels) are responsible for gaps in the sequence alignments. Indel is one of the major sources of evolutionary change at the molecular level. We have examined the patterns of insertions and deletions in the 19 mammalian genomes, and found that deletion events are more common than insertions in the mammalian genomes. Both the number of insertions and deletions decrease rapidly when the gap length increases and single nucleotide indel is the most frequent in all indel events. The frequencies of both insertions and deletions can be described well by power law.

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Tao Shiheng, Fan Yanhui, Wang Wenjuan, Ma Guoji, Liang Lijing and Shi Qi, Patterns of Insertion and Deletion in Mammalian Genomes, Current Genomics 2007; 8 (6) . https://dx.doi.org/10.2174/138920207783406479

DOI https://dx.doi.org/10.2174/138920207783406479	Print ISSN 1389-2029
Publisher Name Bentham Science Publisher	Online ISSN 1875-5488

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