Login

Journal Image
Current Drug Metabolism
ISSN (Print): 1389-2002
ISSN (Online): 1875-5453
VOLUME: 9
ISSUE: 1
DOI: 10.2174/138920008783331176









Metabolic Pathways of T-2 Toxin

img
Author(s): Kamil Kuca, Vlastimil Dohnal, Alena Jezkova and Daniel Jun
Pages 77-82 (6)
Abstract:
Among the naturally-occurring trichothecenes found in food and feed, T-2 toxin is the most potent and toxic mycotoxin. After ingestion of T-2 toxin into the organism, it is processed and eliminated. Some metabolites of this trichothecene are equally toxic or slightly more toxic than T-2 itself, and therefore, the metabolic fate of T-2 toxin has been of great concern. The main reactions in trichothecene metabolism are hydrolysis, hydroxylation and deep oxidation. Typical metabolites of T-2 toxin in an organism are HT-2 toxin, T- 2-triol, T-2-tetraol, 3-hydroxy-T-2, and 3-hydroxy-HT-2 toxin. There are significant differences in the metabolic pathways of T-2 toxin between ruminants and non-ruminants. Ruminants have been more resistant to the adverse effects of T-2 toxin due to microbial degradation within rumen microorganisms. Some plant species are resistant to T-2 toxin, while others are capable of its intake and metabolisation.
Keywords:
T-2 toxin, trichotecene, metabolic pathways, biodegradation, Fusarium
Affiliation:
Department of Food Technology, Faculty of Agronomy, Mendel University of Agriculture and Forestry, 613 00 Brno, Czech Republic.