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Current Pharmaceutical Design
ISSN (Print): 1381-6128
ISSN (Online): 1873-4286
VOLUME: 14
ISSUE: 1
DOI: 10.2174/138161208783330763









Vanilloid Transient Receptor Potential Cation Channels: An Overview

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Author(s): Bernd Nilius, Rudi Vennekens and Grzegorz Owsianik
Pages 18-31 (14)
Abstract:
The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC (‘Canonical’), TRPV (‘Vanilloid’), TRPM (‘Melastatin’), TRPP (‘Polycystin’), TRPML (‘Mucolipin’) and the TRPA (‘Ankyrin’) group. The TRPV subfamily comprises channels that are critically involved in nociception and thermo-sensing (TRPV1, TRPV2, TRPV3, TRPV4) as well as highly Ca2+ selective channels involved in Ca2+ absorption/ reabsorption in mammals (TRPV5, TRPV6). In this review we summarize fundamental physiological properties of all TRPV members in the light of various cellular functions of these channels and their significance in the systemic context of the mammalian organism.
Keywords:
TRP channels, Vannilloid, TRPV, nociception, thermosensing, Ca2+ homeostasis, systemic diseases
Affiliation:
Department Mol Cell Biology,Division of Physiology, KU Leuven, Campus Gasthuisberg, Herestraat 49, bus 802, B-3000 Leuven, Belgium.