Cytokines as Regulators of Atherosclerosis in Murine Models

Author(s): Ziad Mallat, Alain Tedgui.

Journal Name: Current Drug Targets

Volume 8 , Issue 12 , 2007

Abstract:

Atherosclerosis is a chronic inflammatory disease of the arterial wall initiated by a variety of pro-atherogenic stimuli, such as modified epitopes of phospholipids. Both innate and adaptive immune responses contribute to disease initiation and progression. Here, we review the major cytokines involved in this immuno-inflammatory response, and shown to significantly impact disease initiation and/or progression in murine models. We particularly emphasize the role of the regulatory arm of the immune response in disease modulation, and review the major factors that may be involved in its promotion or alteration.

Keywords: TNF receptors, inflammatory response, CD40 receptor, Signaling Pathways, Leptin

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Article Details

VOLUME: 8
ISSUE: 12
Year: 2007
Page: [1264 - 1272]
Pages: 9
DOI: 10.2174/138945007783220588
Price: $58

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