Abstract
This paper aims to review recent developments in the synthesis of quinazolines and quinazolinone derivatives under conditions that include the application of microwave heating in the ring forming step. Recently, two reviews on the synthesis and chemistry of natural and synthetic quinazolines and quinazolinones have been published. This review highlights significant examples where microwave heating has been either synthetically enabling or has provided a key advantage over conventional thermal methods. Wherever possible, this review will focus on chemistry carried out using monomode systems and well-designed type of instrumentation. The review is grouped according to the main heterocycle types in order of increasing complexity; commencing with quinazolines and their derivatives. The microwave-assisted synthesis of quinazolines and quinazolinones will be classified and based on the substitution patterns of the ring system. Syntheses of heterocyclic systems of particular biological or commercial interest are emphasized.
Keywords: Heterocycles, quinazolines, quinazolin-4-ones, natural products, bioactive compounds, microwave irradiation, graphite, solvent-free chemistry
Combinatorial Chemistry & High Throughput Screening
Title: Microwave-Assisted Synthesis of Bioactive Quinazolines and Quinazolinones
Volume: 10 Issue: 10
Author(s): Thierry Besson and Elizabeth Chosson
Affiliation:
Keywords: Heterocycles, quinazolines, quinazolin-4-ones, natural products, bioactive compounds, microwave irradiation, graphite, solvent-free chemistry
Abstract: This paper aims to review recent developments in the synthesis of quinazolines and quinazolinone derivatives under conditions that include the application of microwave heating in the ring forming step. Recently, two reviews on the synthesis and chemistry of natural and synthetic quinazolines and quinazolinones have been published. This review highlights significant examples where microwave heating has been either synthetically enabling or has provided a key advantage over conventional thermal methods. Wherever possible, this review will focus on chemistry carried out using monomode systems and well-designed type of instrumentation. The review is grouped according to the main heterocycle types in order of increasing complexity; commencing with quinazolines and their derivatives. The microwave-assisted synthesis of quinazolines and quinazolinones will be classified and based on the substitution patterns of the ring system. Syntheses of heterocyclic systems of particular biological or commercial interest are emphasized.
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Cite this article as:
Besson Thierry and Chosson Elizabeth, Microwave-Assisted Synthesis of Bioactive Quinazolines and Quinazolinones, Combinatorial Chemistry & High Throughput Screening 2007; 10 (10) . https://dx.doi.org/10.2174/138620707783220356
DOI https://dx.doi.org/10.2174/138620707783220356 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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