Microwave Reactions Under Continuous Flow Conditions

Author(s): Ian R. Baxendale, John J. Hayward, Steven V. Ley.

Journal Name:Combinatorial Chemistry & High Throughput Screening

Volume 10 , Issue 10 , 2007

Abstract:

Microwave chemistry has already impacted significantly on the everyday synthesis of organic molecules. The adoption and integration of this liberating technology has permitted a resurrection of many synthetic transformations that were previously considered too extreme in their conditions (temperatures, pressures, reaction times) to be synthetically useful. Furthermore, whole arrays of additional chemical transformations have been devised under microwave heating that allow access to more diverse chemical architectures via more expedient routes. Continuous flow processing of chemical intermediates taking advantage of the unique heating mechanism and characteristics of microwave irradiation will certainly be the next evolutionary step forward in this area. The synergistic combination afforded by the simultaneous application of these two core processing tools will enhance still further the synthetic capabilities of tomorrows chemists. This short review aims to highlight the current developments and future potential offered by continuous flow microwave mediated synthesis.

Keywords: Microwave, flow, reactor, microreactor, mesoreactor, process intensification, scale up

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Article Details

VOLUME: 10
ISSUE: 10
Year: 2007
Page: [802 - 836]
Pages: 35
DOI: 10.2174/138620707783220374
Price: $58