Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Novel Mitotic Targets and Their Small-Molecule Inhibitors

Author(s): Alexandre V. Ivachtchenko, Alex S. Kiselyov, Sergey E. Tkachenko, Yan A. Ivanenkov, Konstantin V. Balakin.

Abstract:

With several successful anticancer drugs on the market and numerous compounds in clinical developments, antimitotic agents represent an important category of anticancer agents. However, clinical utility of the tubulin-binding agents is somewhat limited due to multiple drug resistance (MDR), poor pharmacokinetics and therapeutic index. There is ongoing need for the modulators of other intracellular targets that result in the same anti-mitotic effect without adverse effects of “traditional” tubulin binders. This review describes progress made to-date in development of novel and emerging biotargets affecting the mitotic events, and their small-molecule modulators.

Keywords: Antimitotic agents, mitotic kinesins, mitotic kinases, separase

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Article Details

VOLUME: 7
ISSUE: 8
Year: 2007
Page: [766 - 784]
Pages: 19
DOI: 10.2174/156800907783220499
Price: $58