RNAi Screening for Therapeutic Targets in Human Malignancies

Author(s): David R. Micklem , James B. Lorens .

Journal Name: Current Pharmaceutical Biotechnology

Volume 8 , Issue 6 , 2007

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Abstract:

The advent of RNA interference (RNAi) based library screening approaches has sparked a surge in loss-of-function genetic screens. Several recent screens have aimed to identify novel regulators of cancer-related phenotypes. These employ various tumor cell types to model malignant cell functions and use different RNAi effector library approaches to reveal a cache of novel tumor regulators. This review surveys recent RNAi screens conducted in transformed human cells.

Keywords: RNA interference, genetic screen, cancer, therapeutic target

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Article Details

VOLUME: 8
ISSUE: 6
Year: 2007
Page: [337 - 343]
Pages: 7
DOI: 10.2174/138920107783018426
Price: $58

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