MicroRNAs in Tumorigenesis

Author(s): Kai Ove Skaftnesmo, Lars Prestegarden, David R. Micklem, James B. Lorens.

Journal Name: Current Pharmaceutical Biotechnology

Volume 8 , Issue 6 , 2007

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Abstract:

Emerging evidence suggests a class of non-coding RNAs termed microRNAs (miRNAs) play a key role in cancer. Since their original discovery in C. elegans in 1993 it has become evident that miRNAs are responsible for an entirely new mechanism of posttranscriptional gene regulation. miRNA expression is widespread in mammalian cells and notably altered in several cancer types. miRNA expression patterns correlate with several aspects of tumorigenesis and miRNA loci have been mapped to frequently altered cancerassociated genomic regions. Inhibition or augmentation of miRNA expression in cancer cells impacts gene expression and affects cell proliferation and survival. Hence, cancer-associated miRNAs may be regarded as a new class of non-coding tumour suppressors and oncogenes capable of regulating several key signalling pathways.

Keywords: RNA, microRNA, cancer

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Article Details

VOLUME: 8
ISSUE: 6
Year: 2007
Page: [320 - 325]
Pages: 6
DOI: 10.2174/138920107783018390
Price: $58

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