Nuclear Factor-Kappa B: From Clone to Clinic

Author(s): Kwang Seok Ahn, Gautam Sethi, Bharat B. Aggarwal.

Journal Name: Current Molecular Medicine

Volume 7 , Issue 7 , 2007

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Abstract:

Nuclear transcription factor κB (NF-κB) was first discovered in 1986 in the nucleus of the B cell as an enhancer in the κ immunoglobulin chain. However, this factor has identified in the cytoplasm in the resting state. When activated in response to inflammatory stimuli, carcinogens, stress, ionizing radiation, and growth factors; NF-κB translocates to the nucleus where it upregulates the expression of over 400 different gene products linked with inflammation, cell survival, proliferation, invasion, and angiogenesis. The activation of NF- κB has now been linked with a variety of inflammatory diseases, including cancer and pulmonary, autoimmune, skin, neurodegenerative, and cardiovascular disorders. Indeed, constitutive NF-κB activation frequently correlates with the proliferation, survival, chemoresistance, radioresistance, and progression of various cancers. Hence, NF-κB has both diagnostic and prognostic applications. In addition, pharmaceutical companies are aggressively pursuing development of inhibitors of NF-κB with therapeutic potential. Thus within last decades this transcription factor, discovered serendipitously, has moved from “clone to clinic”.

Keywords: pulmonary disorders, Multiple sclerosis, Alzheimers disease, Neisseria gonorrhoeae, Antherosclerosis

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Article Details

VOLUME: 7
ISSUE: 7
Year: 2007
Page: [619 - 637]
Pages: 19
DOI: 10.2174/156652407782564363
Price: $58

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