Abstract
Stem cell-based technologies have the potential to help cure a number of cell degenerative diseases. Combinatorial and high throughput screening techniques could provide tools to control and manipulate the self-renewal and differentiation of stem cells. This review chronicles historic and recent progress in the stem cell field involving both pluripotent and multipotent cells, and it highlights relevant cellular signal transduction pathways. This review further describes screens using libraries of soluble, small-molecule ligands, and arrays of molecules immobilized onto surfaces while proposing future trends in similar studies. It is hoped that by reviewing both the stem cell and the relevant high throughput screening literature, this paper can act as a resource to the combinatorial science community.
Keywords: Stem cell, array, self-assembled monolayer, purmorphamine, myoseverin, TSW119, cardiogenol C, reversine, SC1, neuropathiazol
Combinatorial Chemistry & High Throughput Screening
Title: Stem Cells and Combinatorial Science
Volume: 10 Issue: 8
Author(s): Yue Qin Fang, Wan Qing Wong, Yan Wen Yap and Brendan P. Orner
Affiliation:
Keywords: Stem cell, array, self-assembled monolayer, purmorphamine, myoseverin, TSW119, cardiogenol C, reversine, SC1, neuropathiazol
Abstract: Stem cell-based technologies have the potential to help cure a number of cell degenerative diseases. Combinatorial and high throughput screening techniques could provide tools to control and manipulate the self-renewal and differentiation of stem cells. This review chronicles historic and recent progress in the stem cell field involving both pluripotent and multipotent cells, and it highlights relevant cellular signal transduction pathways. This review further describes screens using libraries of soluble, small-molecule ligands, and arrays of molecules immobilized onto surfaces while proposing future trends in similar studies. It is hoped that by reviewing both the stem cell and the relevant high throughput screening literature, this paper can act as a resource to the combinatorial science community.
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Cite this article as:
Fang Qin Yue, Wong Qing Wan, Yap Wen Yan and Orner P. Brendan, Stem Cells and Combinatorial Science, Combinatorial Chemistry & High Throughput Screening 2007; 10 (8) . https://dx.doi.org/10.2174/138620707782507322
DOI https://dx.doi.org/10.2174/138620707782507322 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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