Hydrolytic DNA Cleavage by Non-Lanthanide Metal Complexes

Author(s): Thomas A. Shell, Debra L. Mohler.

Journal Name: Current Organic Chemistry

Volume 11 , Issue 17 , 2007

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Abstract:

Metal complexes that hydrolyze DNA are important, due to their potential use as therapeutic agents, tools in elucidating oligonucleotide structure, and models for naturally-occurring metalloprotein nucleases. Therefore, this review focuses on recent advances in the hydrolysis of DNA and phosphate diester model compounds by non-lanthanide metal complexes.

Keywords: Mononuclear Cobalt Complexes, DNA cleavage, Zinc Complexes, Transition Metal, Dinuclear Iron

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Article Details

VOLUME: 11
ISSUE: 17
Year: 2007
Page: [1525 - 1542]
Pages: 18
DOI: 10.2174/138527207782418654
Price: $58

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