Generic placeholder image

Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Hydrolytic DNA Cleavage by Non-Lanthanide Metal Complexes

Author(s): Thomas A. Shell and Debra L. Mohler

Volume 11, Issue 17, 2007

Page: [1525 - 1542] Pages: 18

DOI: 10.2174/138527207782418654

Price: $65

Abstract

Metal complexes that hydrolyze DNA are important, due to their potential use as therapeutic agents, tools in elucidating oligonucleotide structure, and models for naturally-occurring metalloprotein nucleases. Therefore, this review focuses on recent advances in the hydrolysis of DNA and phosphate diester model compounds by non-lanthanide metal complexes.

Keywords: Mononuclear Cobalt Complexes, DNA cleavage, Zinc Complexes, Transition Metal, Dinuclear Iron


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy