Abstract
The Forkhead transcription factor FOXO3a has emerged as a versatile target for diseases that impact upon neuronal survival, vascular integrity, immune function, and cellular metabolism. Enthusiasm is high to fill a critical treatment void through FOXO3a signaling for several neurodegenerative disorders that include aging, neuromuscular disease, systemic lupus erythematosus, stroke, and diabetic complications. Here we discuss the influence of FOXO3a upon cell survival and longevity, the intricate signal transduction pathways of FOXO3a, insights into present disease models, and the potential clinical translation of FOXO3a signaling into novel therapeutic strategies.
Keywords: Amyotrophic lateral sclerosis, diabetes, apoptosis, FOXO3a, FKHRL1, Akt, erythropoietin, neuromuscular disease, oxidative stress, psychiatric
Current Neurovascular Research
Title: “SLY AS A FOXO”: New Paths with Forkhead Signaling in the Brain
Volume: 4 Issue: 4
Author(s): Kenneth Maiese, Zhao Zhong Chong and Yan Chen Shang
Affiliation:
Keywords: Amyotrophic lateral sclerosis, diabetes, apoptosis, FOXO3a, FKHRL1, Akt, erythropoietin, neuromuscular disease, oxidative stress, psychiatric
Abstract: The Forkhead transcription factor FOXO3a has emerged as a versatile target for diseases that impact upon neuronal survival, vascular integrity, immune function, and cellular metabolism. Enthusiasm is high to fill a critical treatment void through FOXO3a signaling for several neurodegenerative disorders that include aging, neuromuscular disease, systemic lupus erythematosus, stroke, and diabetic complications. Here we discuss the influence of FOXO3a upon cell survival and longevity, the intricate signal transduction pathways of FOXO3a, insights into present disease models, and the potential clinical translation of FOXO3a signaling into novel therapeutic strategies.
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Cite this article as:
Maiese Kenneth, Chong Zhong Zhao and Shang Chen Yan, “SLY AS A FOXO”: New Paths with Forkhead Signaling in the Brain, Current Neurovascular Research 2007; 4 (4) . https://dx.doi.org/10.2174/156720207782446306
DOI https://dx.doi.org/10.2174/156720207782446306 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
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