Abstract
Vaccination is the most cost-efficient and the most powerful medical intervention in the control, prevention and eradication of many diseases that affect human population. Capsular polysaccharide based vaccines have been in use for many decades providing immunity against various bacterial infections. The advent of new efficient and sensitive analytical and synthetic methods in carbohydrate chemistry, together with our increased understanding of glycobiology and glycoim-munology, makes the development of carbohydrate based vaccines against various cancers possible. This review article describes the biological basis of vaccination and summarizes the recent progress in the development of carbohydrate based glycoconjugate vaccines with particular emphasis on structure, function and chemistry of glycoconjugates.
Current Organic Chemistry
Title: Carbohydrate Based Vaccines
Volume: 4 Issue: 6
Author(s): B. Kuberan and R. J. Linhardt
Affiliation:
Abstract: Vaccination is the most cost-efficient and the most powerful medical intervention in the control, prevention and eradication of many diseases that affect human population. Capsular polysaccharide based vaccines have been in use for many decades providing immunity against various bacterial infections. The advent of new efficient and sensitive analytical and synthetic methods in carbohydrate chemistry, together with our increased understanding of glycobiology and glycoim-munology, makes the development of carbohydrate based vaccines against various cancers possible. This review article describes the biological basis of vaccination and summarizes the recent progress in the development of carbohydrate based glycoconjugate vaccines with particular emphasis on structure, function and chemistry of glycoconjugates.
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Cite this article as:
Kuberan B. and Linhardt J. R., Carbohydrate Based Vaccines, Current Organic Chemistry 2000; 4 (6) . https://dx.doi.org/10.2174/1385272003376111
DOI https://dx.doi.org/10.2174/1385272003376111 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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