Abstract
The consumption of fish and omega-3 fatty acids has been associated with reduced morbidity and mortality from coronary heart disease. The precise mechanisms by which fatty acids modulate atherosclerotic vascular disease remain to be defined. Experimental evidence suggests that fatty acids alter the function of the vascular endothelium, a metabolically active tissue that integrates signals between the circulation and the vascular wall. This review focuses on the effects of fatty acids on vascular endothelial nitric oxide production. Endothelial-derived nitric oxide regulates several vascular wall events that participate in the evolution of vascular disease. Impairment of endothelial nitric oxide production has been demonstrated in a variety of conditions such as smoking, diabetes, and hypertension that are risk factors for atherosclerosis. Evidence is reviewed that supports the postulate that both qualitative and quantitative alterations in circulating fatty acid species modulate vascular endothelial nitric oxide production. Although the mechanisms by which fatty acids alter vascular nitric oxide production remain obscure, fatty acid-mediated alterations in endothelial gene expression present a promising area for future investigation.
Current Organic Chemistry
Title: Regulation of Vascular Endothelial Nitric Oxide Production by Fatty Acids
Volume: 4 Issue: 11
Author(s): David S. Calnek and C. Michael Hart
Affiliation:
Abstract: The consumption of fish and omega-3 fatty acids has been associated with reduced morbidity and mortality from coronary heart disease. The precise mechanisms by which fatty acids modulate atherosclerotic vascular disease remain to be defined. Experimental evidence suggests that fatty acids alter the function of the vascular endothelium, a metabolically active tissue that integrates signals between the circulation and the vascular wall. This review focuses on the effects of fatty acids on vascular endothelial nitric oxide production. Endothelial-derived nitric oxide regulates several vascular wall events that participate in the evolution of vascular disease. Impairment of endothelial nitric oxide production has been demonstrated in a variety of conditions such as smoking, diabetes, and hypertension that are risk factors for atherosclerosis. Evidence is reviewed that supports the postulate that both qualitative and quantitative alterations in circulating fatty acid species modulate vascular endothelial nitric oxide production. Although the mechanisms by which fatty acids alter vascular nitric oxide production remain obscure, fatty acid-mediated alterations in endothelial gene expression present a promising area for future investigation.
Export Options
About this article
Cite this article as:
Calnek S. David and Michael Hart C., Regulation of Vascular Endothelial Nitric Oxide Production by Fatty Acids, Current Organic Chemistry 2000; 4 (11) . https://dx.doi.org/10.2174/1385272003375888
DOI https://dx.doi.org/10.2174/1385272003375888 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Perioperative Considerations in Rheumatoid Arthritis Patients
Current Rheumatology Reviews Current Indications for Infective Endocarditis Antibiotic Prophylaxis
Infectious Disorders - Drug Targets Patents on Therapeutic and Cosmetic Applications of Bioactives of Crocus Sativus L. and their Production through Synthetic Biology Methods: A Review
Recent Patents on Biotechnology Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide
Current Drug Metabolism Metabolomics
Current Drug Metabolism Thiazide Diuretics: 50 Years and Beyond
Current Hypertension Reviews Plant Polyphenols and Tumors: From Mechanisms to Therapies, Prevention, and Protection Against Toxicity of Anti-Cancer Treatments
Current Medicinal Chemistry The Role of Genes (and Environmental Stress) in Depression: An Update
Current Psychiatry Reviews Human Immunodeficiency Virus (HIV) and Stroke: Targets for Intervention
Infectious Disorders - Drug Targets The Antidiabetic PPARγ Ligands: An Update on Compounds in Development
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Network Building of Proteins in a Biochemical Pathway: A Computational Biology Related Model for Target Discovery and Drug-Design
Current Bioinformatics Rationally Designed Multitarget Agents Against Inflammation and Pain
Current Medicinal Chemistry Pharmacokinetic and Pharmacodynamic Variability: A Daunting Challenge in Drug Therapy
Current Drug Metabolism miRNAs in Cancer Prevention and Treatment and as Molecular Targets for Natural Product Anticancer Agents
Current Cancer Drug Targets Key Sites for P2X Receptor Function and Multimerization: Overview of Mutagenesis Studies on a Structural Basis
Current Medicinal Chemistry Acute Coronary Syndromes as Auto-Inflammatory Disorders
Current Pharmaceutical Design Micronutrient Biofortification in Rice through New Breeding Techniques (NBTs): Bangladesh Perspective
Current Nutraceuticals Secondary Hypertension: The Ways of Management
Current Vascular Pharmacology Erectile Dysfunction and Diabetes Mellitus: Mechanistic Considerations from Studies in Experimental Models
Current Diabetes Reviews Clinical Profile of Relaxin, a Possible New Drug for Human Use
Current Drug Safety