Bioactive Marine Alkaloids

Author(s): S Urban, S J H. Hickford, J W Blunt, M H G. Munro.

Journal Name: Current Organic Chemistry

Volume 4 , Issue 7 , 2000

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The structures, origins, biogenesis, synthesis and bioactivity of a selection of N-heterocyclic marine alkaloids are reviewed. The emphasis is on compounds poised as potential anticancer drugs: lamellarins (pyrroles), cephalostatins/ritterazines (pyrazines) and ecteinascidins (isoquinolines). Also discussed are examples of bioactive marine alkaloids that have emerged as novel leads. These include manzamines (β-carbolines), variolins (pyridopyrrolopyrimidines) and the pyrroloquinoline family. This review emphasises the role of marine alkaloids as an important source of leads for drug discovery.

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Article Details

Year: 2000
Page: [765 - 807]
Pages: 43
DOI: 10.2174/1385272003376085
Price: $58

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