Abstract
The understanding of cytokine networks and the exploitation of these networks for the treatment of immune and inflammatory diseases as well as cancer depend on in vivo delivery of cytokines. Due to instability of recombinant cytokine proteins, investigators have employed cytokine-encoding gene therapy vectors to induce high levels of cytokine expression in vivo. Numerous gene therapy vectors have been developed recently which are suitable for this purpose. Recent advances in the design of adenovirus, adeno-associated virus, poxvirus, retrovirus, lentivirus, and nonviral vectors are described here. Properties of the various vector systems which determine their usefulness for cytokine gene delivery are compared. The implementations of cytokine-encoding gene therapy vectors for analyzing immune responses and for the therapy of inflammatory disorders, immune disease, infections and cancer are reviewed.
Keywords: Gene Vectors, Cytokine Exprssion, Recombinant, Cancer, Immune, Inflammatory Diseases, adenovirus, Poxvirus, retrovirus, lentivirus, nonviral vectors, gene regulation, Transcription, RNA, Molecular Biology, Wild Type, EIA, ITRs, dCMP, Poxviral, Vaccinia, Retroviral, Leukemia, CD4, MLV, Lentiviral, Pro Inflammatory Matory Vectors, Coxsackie adenovirus receptor, Serotype 2, Murine leukemia, Granulocyte macrophage colony stimulatin, Interleukin, Transforming growth, interferon, Tumor necrosis, Helper T cell, Dendritic
Current Pharmaceutical Design
Title: Gene Vectors for Cytokine Expression In Vivo
Volume: 6 Issue: 6
Author(s): M. M. Hitt and J. Gauldie
Affiliation:
Keywords: Gene Vectors, Cytokine Exprssion, Recombinant, Cancer, Immune, Inflammatory Diseases, adenovirus, Poxvirus, retrovirus, lentivirus, nonviral vectors, gene regulation, Transcription, RNA, Molecular Biology, Wild Type, EIA, ITRs, dCMP, Poxviral, Vaccinia, Retroviral, Leukemia, CD4, MLV, Lentiviral, Pro Inflammatory Matory Vectors, Coxsackie adenovirus receptor, Serotype 2, Murine leukemia, Granulocyte macrophage colony stimulatin, Interleukin, Transforming growth, interferon, Tumor necrosis, Helper T cell, Dendritic
Abstract: The understanding of cytokine networks and the exploitation of these networks for the treatment of immune and inflammatory diseases as well as cancer depend on in vivo delivery of cytokines. Due to instability of recombinant cytokine proteins, investigators have employed cytokine-encoding gene therapy vectors to induce high levels of cytokine expression in vivo. Numerous gene therapy vectors have been developed recently which are suitable for this purpose. Recent advances in the design of adenovirus, adeno-associated virus, poxvirus, retrovirus, lentivirus, and nonviral vectors are described here. Properties of the various vector systems which determine their usefulness for cytokine gene delivery are compared. The implementations of cytokine-encoding gene therapy vectors for analyzing immune responses and for the therapy of inflammatory disorders, immune disease, infections and cancer are reviewed.
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Cite this article as:
Hitt M. M. and Gauldie J., Gene Vectors for Cytokine Expression In Vivo, Current Pharmaceutical Design 2000; 6 (6) . https://dx.doi.org/10.2174/1381612003400551
DOI https://dx.doi.org/10.2174/1381612003400551 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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