Current Molecular Medicine

David W. Li  
College of Medicine
University of Nebraska Medical Center
Omaha, NE
USA

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Role of the Mannose Receptor in the Immune Response

Author(s): V. Apostolopoulos and I. f.c. Mckenzie

Affiliation: The Austin Research Institute, Studley Rd, Heidelberg, VIC, 3084, Australia

Abstract:

The mannose receptor (MR) recognizes a range of carbohydrates present on the surface and cell walls of micro-organisms. The MR is primarily expressed on macrophages and dendritic cells and is involved in MR-mediated endocytosis and phagocytosis. In addition, the MR plays a key role in host defense and provides a link between innate and adaptive immunity. Herein, we will review the role of the MR in innate host defense as well as the recent evidence for its role in the adaptive response, for both humoral and cellular immune responses.

Keywords: Mannose Receptor, Immune Response, mannose receptor (MR), DRUG THERAPY

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Article Details

VOLUME: 1
ISSUE: 4
Page: [469 - 474]
Pages: 6
DOI: 10.2174/1566524013363645
Price: $58