Multivalent Binding in the Design of Bioactive Compounds

Author(s): Dennis Wright, Lynn Usher.

Journal Name: Current Organic Chemistry

Volume 5 , Issue 11 , 2001

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Over the past several years, much research has centered on the development of small molecules that, through multivalent binding interactions, enhance the regulation of fundamental biological functions. The design of a wide range of potential therapeutics focuses on mimicking natural systems that control the biological effect of protein-ligand interactions through multivalency. In this review, the various approaches to achieving multivalency are discussed. Recent advances in the design of multivalent ligands are also presented.

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Article Details

Year: 2001
Page: [1107 - 1131]
Pages: 25
DOI: 10.2174/1385272013374806
Price: $58

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