Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106


Drug Target Discovery by Gene Expression Analysis Cell Cycle Genes

Author(s): M. G. Walker

Affiliation: 1475 Flamingo Way,Sunnyvale, CA, USA


Gene expression microarrays and gene expression databases provide new opportunities for the discovery of drug targets and for determination of a drugs mode of action. We review gene expression analysis methods and describe studies that have identified cell cycle genes using differential expression analysis and co-expression analysis. We present an example of the identification of previously-unrecognized human cell cycle genes, CDCA1 through CDCA8, that are co-expressed with known cell cycle genes including CDC2, CDC7, CDC23, cyclin, MCAK, mki67a, topoisomerase II, and others.

Keywords: Gene Expression Analysis, hepatitis B viral protein, Fisher Exact test, Bonferroni, papillomavirus, hypothetical genes

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Article Details

Page: [73 - 83]
Pages: 11
DOI: 10.2174/1568009013334241