Abstract
The antimitotic agents of the Taxoid series are important substances as anticancer drugs. The efficacy of paclitaxel (Taxol) and docetaxel (Taxotere) has been well demonstrated in the treatment of breast, ovarian and lung cancers. Although these drugs have brought benefits in cancer chemotherapy, they unfortunately possess some disadvantages due to their inefficacy on certain resistant cancers, and due to their toxic side effects. For these reasons, the synthesis of new taxoids with improved biological activity is still an important research area. This review while covering general aspects of taxoid chemistry focuses on recent developments in this area especially those contributing to the improved availability of antimitotic taxoids. Studies of structure-activity relationships are also described.
Keywords: Taxoids, Paclitaxel, Docetaxel, lung cancers, taxoid chemistry, Taxus brevifolia, Taxus baccata, Taxus wallichiana, Taxus Canadensis, Deoxybaccatin
Current Pharmaceutical Design
Title: General and Recent Aspects of the Chemistry and Structure Activity Relationships of Taxoids
Volume: 7 Issue: 13
Author(s): Francoise Gueritte
Affiliation:
Keywords: Taxoids, Paclitaxel, Docetaxel, lung cancers, taxoid chemistry, Taxus brevifolia, Taxus baccata, Taxus wallichiana, Taxus Canadensis, Deoxybaccatin
Abstract: The antimitotic agents of the Taxoid series are important substances as anticancer drugs. The efficacy of paclitaxel (Taxol) and docetaxel (Taxotere) has been well demonstrated in the treatment of breast, ovarian and lung cancers. Although these drugs have brought benefits in cancer chemotherapy, they unfortunately possess some disadvantages due to their inefficacy on certain resistant cancers, and due to their toxic side effects. For these reasons, the synthesis of new taxoids with improved biological activity is still an important research area. This review while covering general aspects of taxoid chemistry focuses on recent developments in this area especially those contributing to the improved availability of antimitotic taxoids. Studies of structure-activity relationships are also described.
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Cite this article as:
Gueritte Francoise, General and Recent Aspects of the Chemistry and Structure Activity Relationships of Taxoids, Current Pharmaceutical Design 2001; 7 (13) . https://dx.doi.org/10.2174/1381612013397429
DOI https://dx.doi.org/10.2174/1381612013397429 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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