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Current Gene Therapy
ISSN (Print): 1566-5232
ISSN (Online): 1875-5631
VOLUME: 1
ISSUE: 3
DOI: 10.2174/1566523013348535      Price:  $58









The Use of Adenoviral Vectors for Genetic Manipulation and Analysis of Primitive Hematopoietic Cells

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Author(s): Craig T. Jordan, Elio F. Vanin and Frank C. Marini
Pages 257-266 (10)
Abstract:
Gene transfer into stem cells has long been studied as a means by which primitive hematopoietic cells could be characterized and manipulated. While a variety of strategies have been attempted, it still remains relatively difficult to perform direct stem cell analysis. In this review, we examine recent studies using adenovirus-based vectors as a means to achieve high-level gene transfer into primitive hematopoietic cell types.
Keywords:
Adenoviral Vectors, Primitive Hematopoietic Cells, Hematopoietic Gene, Fiber Protein, antibody redirection, Hybrid Vectors, Capsid Proteins
Affiliation:
Markey Cancer Center, 800 Rose St. Room CC407, Lexington, KY, 40536-0093, USA