The Use of Adenoviral Vectors for Genetic Manipulation and Analysis of Primitive Hematopoietic Cells

Author(s): Craig T. Jordan, Elio F. Vanin, Frank C. Marini.

Journal Name:Current Gene Therapy

Volume 1 , Issue 3 , 2001

Abstract:

Gene transfer into stem cells has long been studied as a means by which primitive hematopoietic cells could be characterized and manipulated. While a variety of strategies have been attempted, it still remains relatively difficult to perform direct stem cell analysis. In this review, we examine recent studies using adenovirus-based vectors as a means to achieve high-level gene transfer into primitive hematopoietic cell types.

Keywords: Adenoviral Vectors, Primitive Hematopoietic Cells, Hematopoietic Gene, Fiber Protein, antibody redirection, Hybrid Vectors, Capsid Proteins

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Article Details

VOLUME: 1
ISSUE: 3
Year: 2001
Page: [257 - 266]
Pages: 10
DOI: 10.2174/1566523013348535
Price: $58