Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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The Use of Adenoviral Vectors for Genetic Manipulation and Analysis of Primitive Hematopoietic Cells

Author(s): Craig T. Jordan, Elio F. Vanin and Frank C. Marini

Affiliation: Markey Cancer Center, 800 Rose St. Room CC407, Lexington, KY, 40536-0093, USA

Keywords: Adenoviral Vectors, Primitive Hematopoietic Cells, Hematopoietic Gene, Fiber Protein, antibody redirection, Hybrid Vectors, Capsid Proteins

Abstract:

Gene transfer into stem cells has long been studied as a means by which primitive hematopoietic cells could be characterized and manipulated. While a variety of strategies have been attempted, it still remains relatively difficult to perform direct stem cell analysis. In this review, we examine recent studies using adenovirus-based vectors as a means to achieve high-level gene transfer into primitive hematopoietic cell types.

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Article Details

VOLUME: 1
ISSUE: 3
Page: [257 - 266]
Pages: 10
DOI: 10.2174/1566523013348535