Abstract
Farnesyl protein transferase (FPT) inhibition is an interesting and promising approach to non-cytotoxic anticancer therapy. Research in this area has resulted in several orally active compounds that are currently in clinical evaluation. This review focuses on FPT inhibitors in clinical trials and concentrates on the benzocycloheptapyridine class, with details on the discovery and development of SCH 66336, currently in Phase II clinical trials.
Keywords: Farnesyl Protein Transferase Inhibition, Anti-tumor Therapy, farnesyl protein transferase, Farnesylation, Geranlylgeranylation, carboxymethyl transferase, FPT Enzyme Assay, COS Assay, Pharmacokinetic Assay (PK), Potent FPT Inhibitors
Current Medicinal Chemistry
Title: Farnesyl Protein Transferase Inhibition: A Novel Approach to Anti-tumor
Volume: 8 Issue: 12
Author(s): A. K. Ganguly, R. J. Doll and V.M. Girijavallabhan
Affiliation:
Keywords: Farnesyl Protein Transferase Inhibition, Anti-tumor Therapy, farnesyl protein transferase, Farnesylation, Geranlylgeranylation, carboxymethyl transferase, FPT Enzyme Assay, COS Assay, Pharmacokinetic Assay (PK), Potent FPT Inhibitors
Abstract: Farnesyl protein transferase (FPT) inhibition is an interesting and promising approach to non-cytotoxic anticancer therapy. Research in this area has resulted in several orally active compounds that are currently in clinical evaluation. This review focuses on FPT inhibitors in clinical trials and concentrates on the benzocycloheptapyridine class, with details on the discovery and development of SCH 66336, currently in Phase II clinical trials.
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Cite this article as:
Ganguly K. A., Doll J. R. and Girijavallabhan V.M., Farnesyl Protein Transferase Inhibition: A Novel Approach to Anti-tumor, Current Medicinal Chemistry 2001; 8 (12) . https://dx.doi.org/10.2174/0929867013372021
DOI https://dx.doi.org/10.2174/0929867013372021 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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