Abstract
Nuclear magnetic resonance (NMR) has become established as a powerful tool for qualitative and semi-quantitative analysis of complex mixtures of body fluids, intact cells, tissues and their extracts. Such studies are finding increasing applications in clinical and medical sciences. 1H and 31P NMR provide a noninvasive probe of high-energy compounds, amino acids, and compounds of phospholipid metabolism in cells and tissues. 13C NMR has been used to measure and characterize high concentration of molecules. The introduction of 13C-labeled substrates allows one to follow metabolism by the 13C NMR method. In this review, we have described one dimensional inverse detection techniques and various two dimensional homonuclear and heteronuclear methods with special emphasis on methods for studies of cells. Application of NMR to detect me tabolites in various cells and tissues has been discussed with illustrative examples, to highlight the type of information NMR can provide.
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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