Abstract
Zaragozic acids (or squalestatins) are very potent inhibitors of squalene synthase. They or simpler analogs have potential as drugs for lowering the endogenous level of cholesterol in human serum. These compounds are Ras farnesyltransferase inhibitors and might become antitumor drugs. They are also antifungal agents. This account presents synthetic studies subsequent to those reviewed by Nadin and Nicolaou (1). A wealth of new chemistry has been developed for the generation of highly oxygenated 2,8-dioxabicyclo(3.2.1)octane-3,4,5-tricarboxylic triacids and analogs, so demonstrating the fascination of synthetic chemists for zaragozic acids.
Keywords: Zaragozic Acids, farnesyltransferase, 3,4,5-tricarboxylic, isopentyladenine,, sterol 27-hydroxylase,, intramolecular acetalization, 5-phenylthiofuran-2-carboxylic acid, allylmagnesium bromide, 6,7-dideoxysqualestatin, Ozonolysis
Current Organic Chemistry
Title: Recent Progress in the Synthesis of Zaragozic Acids and Analogs
Volume: 5 Issue: 6
Author(s): Nathalie Jotterand and Pierre Vogel
Affiliation:
Keywords: Zaragozic Acids, farnesyltransferase, 3,4,5-tricarboxylic, isopentyladenine,, sterol 27-hydroxylase,, intramolecular acetalization, 5-phenylthiofuran-2-carboxylic acid, allylmagnesium bromide, 6,7-dideoxysqualestatin, Ozonolysis
Abstract: Zaragozic acids (or squalestatins) are very potent inhibitors of squalene synthase. They or simpler analogs have potential as drugs for lowering the endogenous level of cholesterol in human serum. These compounds are Ras farnesyltransferase inhibitors and might become antitumor drugs. They are also antifungal agents. This account presents synthetic studies subsequent to those reviewed by Nadin and Nicolaou (1). A wealth of new chemistry has been developed for the generation of highly oxygenated 2,8-dioxabicyclo(3.2.1)octane-3,4,5-tricarboxylic triacids and analogs, so demonstrating the fascination of synthetic chemists for zaragozic acids.
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Cite this article as:
Jotterand Nathalie and Vogel Pierre, Recent Progress in the Synthesis of Zaragozic Acids and Analogs, Current Organic Chemistry 2001; 5 (6) . https://dx.doi.org/10.2174/1385272013375328
DOI https://dx.doi.org/10.2174/1385272013375328 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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