Abstract
This review starts from a brief introduction followed by the list of commercial antimalarial drug. According to the nature of chemical entities, these drugs have been divided into the following categories- Quinolines, pyrimidines, amidinies, guanidines, sulfonamides, sulfones, acridines, antibiotics and sesquiterpene lactones. The site of action and status of the antimalarial drugs have been described against each category. Abrief description of reasons behind the search of a new antimalarilal drug have been discussed. Finally, the review deals the well known biochemical target sites such as folate metabolism, pyrimidine metabolism and polyamines for the designing of antimalarial drugs. The detail description of the newly discovered biochemical target sites, - tublin and DNA topoisomerases, have been highlighted. In the conclusion section, we have discussed the future strategies for the chemotherapy of malaria.
Current Medicinal Chemistry
Title: Present Trends and Future Strategy in Chemotherapy of Malaria
Volume: 8 Issue: 13
Author(s): P.M. S. Chauhan and Sanjay K. Srivastava
Affiliation:
Abstract: This review starts from a brief introduction followed by the list of commercial antimalarial drug. According to the nature of chemical entities, these drugs have been divided into the following categories- Quinolines, pyrimidines, amidinies, guanidines, sulfonamides, sulfones, acridines, antibiotics and sesquiterpene lactones. The site of action and status of the antimalarial drugs have been described against each category. Abrief description of reasons behind the search of a new antimalarilal drug have been discussed. Finally, the review deals the well known biochemical target sites such as folate metabolism, pyrimidine metabolism and polyamines for the designing of antimalarial drugs. The detail description of the newly discovered biochemical target sites, - tublin and DNA topoisomerases, have been highlighted. In the conclusion section, we have discussed the future strategies for the chemotherapy of malaria.
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Cite this article as:
Chauhan S. P.M. and Srivastava K. Sanjay, Present Trends and Future Strategy in Chemotherapy of Malaria, Current Medicinal Chemistry 2001; 8 (13) . https://dx.doi.org/10.2174/0929867013371851
DOI https://dx.doi.org/10.2174/0929867013371851 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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