Significance of Total Synthesis of Bioactive Compounds

Author(s): Kuniaki Tatsuta.

Journal Name: Current Organic Chemistry

Volume 5 , Issue 2 , 2001

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The first total synthesis and development of a variety of bioactive compounds have been accomplished mainly by using carbohydrates, if any, as chiral sources. The target molecules are macrolide antibiotics, aminoglycoside antibiotics, antifungal antibiotics, antitumor antibiotics, a side-chain of b-lactam antibiotics, enzyme inhibitors including glycosidase inhibitors, central nervous system - affecting products, nonsteroidal progesterone receptor ligands, mussel-attachment inhibitors and so on.

Keywords: Total synthesis, aminoglycoside antibiotics, macrolide, enzyme inhibitors, ansa, oleandomycin, Cyclophellitols, Glyoxalase, Syncytium formation, terpestacin

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Article Details

Year: 2001
Page: [207 - 231]
Pages: 25
DOI: 10.2174/1385272013375670
Price: $58