Sugar Nucleotide-Modifying Enzymes

Author(s): Martin E. Tanner.

Journal Name: Current Organic Chemistry

Volume 5 , Issue 2 , 2001

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Abstract:

Sugar nucleotides serve as the activated forms of carbohydrates that are used in a wide range of biosynthetic pathways. Instead of building up the sugar nucleotide from the free sugar itself, nature often chooses to modify the donor portion of a pre-existing sugar nucleotide in a biosynthetically efficient manner. In doing so a rich variety of catalytic strategies are employed and this review focuses on recent mechanistic and structural studies of the sugar nucleotide-modifying enzymes. The review is organized around the types of reactions catalyzed and contains the following sections Epimerases/Mutases/Decarboxylases, Eliminations and Substitutions, Oxidation and Reduction, and Substitutions on the Periphery of Sugar Nucleotides.

Keywords: Sugar Nucleotide, Modifying Enzymes, biosynthetic pathway, Decarboxylase, Dehydratases, Branched changed, UDP glucose, MurA reactio

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2001
Page: [169 - 192]
Pages: 24
DOI: 10.2174/1385272013375643
Price: $58

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