Abstract
A recent estimate suggests roughly 70percent of current lead compounds in modern drug discovery derive directly from the natural products, many of which are glycosylated bacterial metabolites. Thus, bacterial glycosyltransferases and their corresponding sugar substrates contribute significantly to the diversity of pharmaceutically important metabolites. This review summarizes (i) the role that carbohydrates contribute to biologically active bacterial metabolites, (ii ) a sequence homology classification of known glycosyltransferases from these systems and (iii) the potential impact pathway engineering and combinatorial biocatalysis may have on increasing carbohydrate-ligand diversity. While the number of glycosylated bacterial metabolites is vast, this review limits itself to glycosides with considerable published information pertaining to biological activity and biosynthesis.
Keywords: Enzymatic glycosylatio, bioactive, bacterial metabolites, glycosyltransferases, chromoprotein, anthracyclines, pluramycins, indolocarbazoles, pooyenes, angucylines, amycolatopsis, macrolides
Current Organic Chemistry
Title: Natures Carbohydrate Chemists The Enzymatic Glycosylation of Bioactive Bacterial Metabolites
Volume: 5 Issue: 2
Author(s): Jon S. Thorson, Thomas J. Hosted Jr., Jiqing Jiang, John B. Biggins and Joachim Ahlert
Affiliation:
Keywords: Enzymatic glycosylatio, bioactive, bacterial metabolites, glycosyltransferases, chromoprotein, anthracyclines, pluramycins, indolocarbazoles, pooyenes, angucylines, amycolatopsis, macrolides
Abstract: A recent estimate suggests roughly 70percent of current lead compounds in modern drug discovery derive directly from the natural products, many of which are glycosylated bacterial metabolites. Thus, bacterial glycosyltransferases and their corresponding sugar substrates contribute significantly to the diversity of pharmaceutically important metabolites. This review summarizes (i) the role that carbohydrates contribute to biologically active bacterial metabolites, (ii ) a sequence homology classification of known glycosyltransferases from these systems and (iii) the potential impact pathway engineering and combinatorial biocatalysis may have on increasing carbohydrate-ligand diversity. While the number of glycosylated bacterial metabolites is vast, this review limits itself to glycosides with considerable published information pertaining to biological activity and biosynthesis.
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Cite this article as:
Thorson S. Jon, Hosted Jr. J. Thomas, Jiang Jiqing, Biggins B. John and Ahlert Joachim, Natures Carbohydrate Chemists The Enzymatic Glycosylation of Bioactive Bacterial Metabolites, Current Organic Chemistry 2001; 5 (2) . https://dx.doi.org/10.2174/1385272013375706
DOI https://dx.doi.org/10.2174/1385272013375706 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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