Natures Carbohydrate Chemists The Enzymatic Glycosylation of Bioactive Bacterial Metabolites

Author(s): Jon S. Thorson, Thomas J. Hosted Jr., Jiqing Jiang, John B. Biggins, Joachim Ahlert.

Journal Name: Current Organic Chemistry

Volume 5 , Issue 2 , 2001

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A recent estimate suggests roughly 70percent of current lead compounds in modern drug discovery derive directly from the natural products, many of which are glycosylated bacterial metabolites. Thus, bacterial glycosyltransferases and their corresponding sugar substrates contribute significantly to the diversity of pharmaceutically important metabolites. This review summarizes (i) the role that carbohydrates contribute to biologically active bacterial metabolites, (ii ) a sequence homology classification of known glycosyltransferases from these systems and (iii) the potential impact pathway engineering and combinatorial biocatalysis may have on increasing carbohydrate-ligand diversity. While the number of glycosylated bacterial metabolites is vast, this review limits itself to glycosides with considerable published information pertaining to biological activity and biosynthesis.

Keywords: Enzymatic glycosylatio, bioactive, bacterial metabolites, glycosyltransferases, chromoprotein, anthracyclines, pluramycins, indolocarbazoles, pooyenes, angucylines, amycolatopsis, macrolides

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Article Details

Year: 2001
Page: [139 - 167]
Pages: 29
DOI: 10.2174/1385272013375706
Price: $58

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