Biologic Properties of Non-Antibiotic, Chemically Modified Tetracyclines (CMTs): A Structured, Annotated Bibliography

Robert   A.   Greenwald; Lorne   M.   Golub

Abstract

The first paper reporting on a potentially important medical property of a non-antimicrobial tetracycline appeared in 1987. Since then, a literature of over 75 papers has supported the therapeutic potential of this class of compounds. In this review, this literature is grouped and organized with commentary on the data which has been published to date. The biomedical applicability of these discoveries obviously covers a wide range of medical conditions and clearly justifies their continued development.

Keywords: Non Antibiotics, Modified tetracycline, antimicrobial properties, enzyme inhibition, animal models, collagenolytic activity, cmts inhibit MMP 13, Enhance cytokine, Cartilage degradation, non specific proteolysis, induce apoptosis, metabolic bone disease, arthritic dog