Analytical Techniques for Small Molecule Solid Phase Synthesis

Author(s): Jan J. Scicinski, Miles S. Congreve, Corinne Kay, Steven V. Ley.

Journal Name: Current Medicinal Chemistry

Volume 9 , Issue 23 , 2002

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Although resin-based chemistry offers many practical advantages over conventional solution phase for the synthesis of combinatorial libraries, effective monitoring of reactions conducted on the support remains a challenge. A number of techniques have been developed to enable the analysis of solid phase organic synthesis either by monitoring the resin-bound species directly or by the analysis of small quantities of material cleaved from the support. This review outlines some of the principles of the various techniques for the analysis of intermediates and products obtained from solid-phase chemistry.

Keywords: small molecule solid phase synthesis, solid phase organic chemistry

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Article Details

Year: 2002
Page: [2103 - 2127]
Pages: 25
DOI: 10.2174/0929867023368737
Price: $58

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