Interferon-α / β-Receptor Interactions: A Complex Story Unfolding

Author(s): Raj Deonarain, David C.M. Chan, Leonidas C. Platanias, Eleanor N. Fish.

Journal Name: Current Pharmaceutical Design

Volume 8 , Issue 24 , 2002

Abstract:

The Type I interferons (IFN-α / ß) exhibit pleiotropic biological activities. Notably, the different IFN subtypes activate the same cell surface receptor complex to mediate variable responses. Accumulating evidence suggests that distinct differences in critical amino acid residues among the different IFN-αs and IFN-ß determine the nature of the ligand-receptor interaction and the subsequent responses. This review focuses on IFN-receptor interactions, the key residues involved in this interaction and the potential for targeted modifications of the ligand to enhance bioactivity.

Keywords: interferon, ifnar1, ifnar2, binding residues

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Article Details

VOLUME: 8
ISSUE: 24
Year: 2002
Page: [2131 - 2137]
Pages: 7
DOI: 10.2174/1381612023393288
Price: $58

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