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Current Molecular Medicine
ISSN (Print): 1566-5240
ISSN (Online): 1875-5666
VOLUME: 2
ISSUE: 6
DOI: 10.2174/1566524023362195      Price:  $58









Cross-talk Between Hematopoiesis and Angiogenesis Signaling Pathways

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Author(s): Domenico Ribatti, Angelo Vacca, Beatrice Nico, Roberto Ria and Franco Dammacco
Pages 537-543 (7)
Abstract:
The relationship between hematopoietic cells and endothelial cells has been seen as an indication that a common progenitor, the hemangioblast, gives rise to both cell types in the yolk sac, the initial site of hematopoiesis and blood vessel formation during mammalian development. The existence of angioblast-like circulating endothelial precursor cells in adults humans has recently been suggested. In this review, we have summarized the principle mechanisms involved in the cross-talk signaling pathway between hematopoiesis and angiogenesis in order to further understand how the hematopoietic and vascular systems are established during the development.
Keywords:
cross-talk, hematopoiesis, signaling pathways, common progenitor, mammalian development, hemangioblast
Affiliation:
Department of Human Anatomy and Histology, Policlinico, Piazza Giulio Cesare, 11, I-70124Bari (Italy)