Cross-talk Between Hematopoiesis and Angiogenesis Signaling Pathways
Domenico Ribatti, Angelo Vacca, Beatrice Nico, Roberto Ria and Franco Dammacco
Affiliation: Department of Human Anatomy and Histology, Policlinico, Piazza Giulio Cesare, 11, I-70124Bari (Italy)
The relationship between hematopoietic cells and endothelial cells has been seen as an indication that a common progenitor, the hemangioblast, gives rise to both cell types in the yolk sac, the initial site of hematopoiesis and blood vessel formation during mammalian development. The existence of angioblast-like circulating endothelial precursor cells in adults humans has recently been suggested. In this review, we have summarized the principle mechanisms involved in the cross-talk signaling pathway between hematopoiesis and angiogenesis in order to further understand how the hematopoietic and vascular systems are established during the development.
Keywords: cross-talk, hematopoiesis, signaling pathways, common progenitor, mammalian development, hemangioblast
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