Current Molecular Medicine

David W. Li  
College of Medicine
University of Nebraska Medical Center
Omaha, NE


Cross-talk Between Hematopoiesis and Angiogenesis Signaling Pathways

Author(s): Domenico Ribatti, Angelo Vacca, Beatrice Nico, Roberto Ria and Franco Dammacco

Affiliation: Department of Human Anatomy and Histology, Policlinico, Piazza Giulio Cesare, 11, I-70124Bari (Italy)


The relationship between hematopoietic cells and endothelial cells has been seen as an indication that a common progenitor, the hemangioblast, gives rise to both cell types in the yolk sac, the initial site of hematopoiesis and blood vessel formation during mammalian development. The existence of angioblast-like circulating endothelial precursor cells in adults humans has recently been suggested. In this review, we have summarized the principle mechanisms involved in the cross-talk signaling pathway between hematopoiesis and angiogenesis in order to further understand how the hematopoietic and vascular systems are established during the development.

Keywords: cross-talk, hematopoiesis, signaling pathways, common progenitor, mammalian development, hemangioblast

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Article Details

Page: [537 - 543]
Pages: 7
DOI: 10.2174/1566524023362195