Abstract
Microchimerism has been defined by the presence of a low number of circulating cells transferred from one individual to another. This transfer takes place naturally during pregnancy, between mother and fetus and / or between fetuses in multi-gestational pregnancies. Furthermore, the establishment of microchimerism can also occur during blood transfusion and organ transplants. Microchimeric cells have been implicated in health and disease. Microchimerism has been correlated with the hyporesponsiveness of the maternal immune system towards the fetal allograft and with the longevity of organ transplants. However, maternal microchimeric cells have been implicated in diseases of the neonate including neonatal graft-versus-host disease, severe combined immunodeficiency and erythema toxicum neonatorum. And more recently, microchimeric cells have been implicated in the pathogenesis of autoimmune diseases including systemic sclerosis and myositis.
Keywords: microchimerism, disease, circulating cells, multi-gestational pregnancies, organ transplants, graft-versus-host, autoimmune diseases, myositis
Current Molecular Medicine
Title: Microchimerism in Health and Disease
Volume: 2 Issue: 6
Author(s): Carol M. Artlett
Affiliation:
Keywords: microchimerism, disease, circulating cells, multi-gestational pregnancies, organ transplants, graft-versus-host, autoimmune diseases, myositis
Abstract: Microchimerism has been defined by the presence of a low number of circulating cells transferred from one individual to another. This transfer takes place naturally during pregnancy, between mother and fetus and / or between fetuses in multi-gestational pregnancies. Furthermore, the establishment of microchimerism can also occur during blood transfusion and organ transplants. Microchimeric cells have been implicated in health and disease. Microchimerism has been correlated with the hyporesponsiveness of the maternal immune system towards the fetal allograft and with the longevity of organ transplants. However, maternal microchimeric cells have been implicated in diseases of the neonate including neonatal graft-versus-host disease, severe combined immunodeficiency and erythema toxicum neonatorum. And more recently, microchimeric cells have been implicated in the pathogenesis of autoimmune diseases including systemic sclerosis and myositis.
Export Options
About this article
Cite this article as:
Artlett M. Carol, Microchimerism in Health and Disease, Current Molecular Medicine 2002; 2 (6) . https://dx.doi.org/10.2174/1566524023362131
DOI https://dx.doi.org/10.2174/1566524023362131 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nucleic Acids as Therapeutic Agents
Current Topics in Medicinal Chemistry Statin-Induced Myotoxicity: Pharmacokinetic Differences among Statins and the Risk of Rhabdomyolysis, with Particular Reference to Pitavastatin
Current Vascular Pharmacology Approaches to Optimize Gene Therapy for the Treatment of Hematologic Malignancies: Overcoming the Obstacles
Current Gene Therapy Musculoskeletal Adverse Drug Reactions: A Review of Literature and Data from ADR Spontaneous Reporting Databases
Current Drug Safety Chemokines in Rheumatic Diseases
Current Drug Targets Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies
Recent Patents on Inflammation & Allergy Drug Discovery Editorial from Editor-in-Chief
Current Rheumatology Reviews Recent Advances in the Treatment of Interstitial Lung Disease in Patients with Polymyositis/Dermatomyositis
Endocrine, Metabolic & Immune Disorders - Drug Targets Patient Perspectives in OMERACT Provide an Anchor for Future Metric Development and Improved Approaches to Healthcare Delivery in Connective Tissue Disease Related Interstitial Lung Disease (CTD-ILD)
Current Respiratory Medicine Reviews Relationship Between Polymorphisms of Interleukin-1 Receptor Antagonist (IL-1Ra) Genes and Susceptibility to Systemic Lupus Erythematosus in Iranian Population
Current Rheumatology Reviews Amide-linked Ethanolamine Conjugate of Gemfibrozil as a Profound HDL Enhancer: Design, Synthesis, Pharmacological Screening and Docking Study
Current Drug Discovery Technologies Towards a Personalised Approach to Managing Influenza Infections in Infants and Children – Food for Thought and a Note on Oseltamivir
Infectious Disorders - Drug Targets Expression and Secretion of Wild Type and Mutant GNE Proteins in Dictyostelium discoideum
CNS & Neurological Disorders - Drug Targets Update on Intravenous Immunoglobulins (IVIg) Mechanisms of Action and Off- Label use in Autoimmune Diseases
Current Pharmaceutical Design Pediatric Cutaneous Graft Versus Host Disease: A Review
Current Pediatric Reviews Update on the Rheumatologic Manifestations of Malignancy
Current Cancer Therapy Reviews Severe Influenza: Clinical Features and Treatment Options
Current Respiratory Medicine Reviews Neuromuscular Disorders in Left Ventricular Hypertrabeculation/Noncompaction
Current Pharmaceutical Design Current Evidence and Future Perspectives on Anti-platelet and Statin Pharmacotherapy for Patients with Symptomatic Peripheral Arterial Disease
Current Vascular Pharmacology Herb-Drug Interactions in Neurological Disorders: A Critical Appraisal
Current Drug Metabolism