Crystal Structures of Acridines Complexed with Nucleic Acids

Author(s): Adrienne Adams.

Journal Name: Current Medicinal Chemistry

Volume 9 , Issue 18 , 2002


Abstract:

Acridines have been used as chemotherapeutic agents against bacteria, protozoa and fungi, and they now find important use as anticancer drugs. There is a paucity of crystal structures of acridine-DNA complexes above the dinucleotide level, but recent structures of acridinecarboxamide topoisomerase II poisons complexed to hexanucleotides have allowed a molecular rationalization of their structure-activity relationships for cytotoxicity and for their kinetics of DNA binding.

Keywords: acridines, crystal structures, nucleic acids, DNA, complexes, acridine-4-carboxamides

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Article Details

VOLUME: 9
ISSUE: 18
Year: 2002
Page: [1667 - 1675]
Pages: 9
DOI: 10.2174/0929867023369259
Price: $65

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