Current Molecular Medicine

David W. Li  
College of Medicine
University of Nebraska Medical Center
Omaha, NE
USA

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Current Developments in Human Molecular Cytogenetic Techniques

Author(s): Thomas Liehr and Uwe Claussen

Affiliation: Institut für Humangenetikund Anthropologie, D-07740 Jena, Germany

Abstract:

In the last decade a variety of fluorescence in situ hybridization (FISH) assays have been developed. In this paper we present an overview on the currently available methods in molecular cytogenetics, highlighting their advantages and limitations, as well as their applications. Even though one has to be impressed by the total number of new techniques introduced in molecular cytogenetics, one has to be aware of the fact that it is not the brilliance of a technique that is important but the scientific question that can be addressed by it. In this review special emphasis has given in describing possible strategies for the characterization of marker and derivative chromosomes in tumor- and clinical cytogenetics.

Keywords: Cytogenetic Techniques, Genomic Hybridization, Chromosome Painting Probes, Multicolor Banding, Immunophenotyping, Interphase Nucleus, GTG-banding

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Article Details

VOLUME: 2
ISSUE: 3
Page: [283 - 297]
Pages: 15
DOI: 10.2174/1566524024605725
Price: $58