Regulation of T cell Apoptosis during the Immune Response

Author(s): Sven Baumann, Andreas Krueger, Sabine Kirchhoff, Peter H. Krammer.

Journal Name:Current Molecular Medicine

Volume 2 , Issue 3 , 2002

Abstract:

Apoptosis of T-lymphocytes is a fundamental process regulating antigen receptor repertoire selection during T cell maturation and homeostasis of the immune system. It also plays a key role in elimination of autoreactive lymphocytes. Resting mature T cells are activated by antigen to elicit an appropriate immune response. In contrast, preactivated T cells undergo activation-induced cell death (AICD) in response to TCR triggering alone. Thus, death by apoptosis is essential for function, growth and differentiation of T-lymphocytes. This review focuses on apoptosis mechanisms involved in T cell development and during the course of an immune response.

Keywords: T cell Apoptosis, Immune Response, CD95 SIGNALING PATHWAY, THYMOCYTE SELECTION, DEATH RECEPTORS, Death domain, FLICE inhibitory protein

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2002
Page: [257 - 272]
Pages: 16
DOI: 10.2174/1566524024605671
Price: $58

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