Current Molecular Medicine

David W. Li  
College of Medicine
University of Nebraska Medical Center
Omaha, NE


Regulation of T cell Apoptosis during the Immune Response

Author(s): Sven Baumann, Andreas Krueger, Sabine Kirchhoff and Peter H. Krammer

Affiliation: German Cancer ResearchCenter (DKFZ), Division of Immunogenetics (G0300), Im NeuenheimerFeld 280, D-69120 Heidelberg, Germany


Apoptosis of T-lymphocytes is a fundamental process regulating antigen receptor repertoire selection during T cell maturation and homeostasis of the immune system. It also plays a key role in elimination of autoreactive lymphocytes. Resting mature T cells are activated by antigen to elicit an appropriate immune response. In contrast, preactivated T cells undergo activation-induced cell death (AICD) in response to TCR triggering alone. Thus, death by apoptosis is essential for function, growth and differentiation of T-lymphocytes. This review focuses on apoptosis mechanisms involved in T cell development and during the course of an immune response.

Keywords: T cell Apoptosis, Immune Response, CD95 SIGNALING PATHWAY, THYMOCYTE SELECTION, DEATH RECEPTORS, Death domain, FLICE inhibitory protein

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Page: [257 - 272]
Pages: 16
DOI: 10.2174/1566524024605671
Price: $58