Regulation of T cell Apoptosis during the Immune Response
Sven Baumann, Andreas Krueger, Sabine Kirchhoff and Peter H. Krammer
Affiliation: German Cancer ResearchCenter (DKFZ), Division of Immunogenetics (G0300), Im NeuenheimerFeld 280, D-69120 Heidelberg, Germany
Apoptosis of T-lymphocytes is a fundamental process regulating antigen receptor repertoire selection during T cell maturation and homeostasis of the immune system. It also plays a key role in elimination of autoreactive lymphocytes. Resting mature T cells are activated by antigen to elicit an appropriate immune response. In contrast, preactivated T cells undergo activation-induced cell death (AICD) in response to TCR triggering alone. Thus, death by apoptosis is essential for function, growth and differentiation of T-lymphocytes. This review focuses on apoptosis mechanisms involved in T cell development and during the course of an immune response.
Keywords: T cell Apoptosis, Immune Response, CD95 SIGNALING PATHWAY, THYMOCYTE SELECTION, DEATH RECEPTORS, Death domain, FLICE inhibitory protein
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