Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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Oncolytic Viruses: Programmable Tumour Hunters

Author(s): J. C. Bell, K. A. Garson, B. D. Lichty, F. D. Stojdl.

Abstract:

Despite significant improvements in early detection and refinements of therapeutic protocols over the last several decades, cancer remains one of the leading causes of death in North America. In particular, treatment of metastatic cancers is a highly desirable and yet still elusive goal of the oncologist. One strategy which holds promise is the use of self replicating viral strains with the ability to specifically kill tumour but not normal cells. These so-called “oncolytic viruses” are in general, attenuated for growth in normal cells but are able to exploit tumour specific, genetic defects to gain a growth advantage. In this review, we will discuss the virus:host cell interactions which help form the niche occupied by oncolytic viruses. The current and potential clinical applications / limitations will be discussed for oncolytic viruses from the herpesvirus, adenoviruses, picornavirus, rhabdovirus, and paramyxovirus families.

Keywords: Oncolytic Viruses, Tumour Hunters, Paramyxoviruses, Fibre Knob

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2002
Page: [243 - 254]
Pages: 12
DOI: 10.2174/1566523024605582
Price: $58