Examining the Relationship between Cancer Invasion / Metastasis and Drug Resistance

Y.      Liang; S.      McDonnell; M.      Clynes

Abstract

Studies of cancer invasion / metastasis and drug resistance have in the past generally proceeded along the separate pathways of research. Recently, however, interest has been focused on the possible relationship between drug resistance and cancer invasion and metastasis. A relationship between these two phenotypes has been demonstrated by two types of observation: firstly, some tumor cells selected for resistance to drugs are more invasive / metastatic relative to non-resistant parental cells, secondly, in some cases, secondary (more metastatic) tumors are more resistant to chemotherapeutic drugs than their primary counterparts. In other instances reported in the literature, no correlation is seen between drug exposure / resistance and cancer invasion / metastasis. The possibility that treatment with some chemotherapeutic drugs may be able to promote cancer invasion and metastasis needs further investigation because of its potential clinical relevance. A better understanding of any relationship between drug resistance and cancer invasion could lead to more effective cancer treatment.

Keywords: cancer invasion, drug resistance, phenotypes, effective cancer treatment, circulatory anatomy, metastatic tumors, cytokeratins and vimentin

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