Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge


The Palmitoylethanolamide Family: A New Class of Anti-Inflammatory Agents ?

Author(s): Didier M. Lambert, Severine Vandevoorde, Kent-Olov Jonsson and Christopher J. Fowler

Affiliation: Unite de Chimiepharmaceutique et de Radiopharmacie, Ecole de Pharmacie, Faculte deMedecine, Universite catholique de Louvain, UCL-CMFA 73.40, 73,avenue Emmanuel Mounier, B-1200 Brussels, Belgium


The discovery of anandamide as an endogenous ligand for the cannabinoid receptors has led to a resurgence of interest in the fatty acid amides. However, N-palmitoylethanolamine (PEA), a shorter and fully saturated analogue of anandamide, has been known since the fifties. This endogenous compound is a member of the N-acylethanolamines, found in most mammalian tissues. PEA is accumulated during inflam-mation and has been demonstrated to have a number of anti-inflammatory effects, including beneficial effects in clinically relevant animal models of inflammatory pain. It is now engaged in phase II clinical development, and two studies regarding the treatment of chronic lumbosciatalgia and multiple sclerosis are in progress. However, its precise mechanism of action remains debated. In the present review, the biochemical and pharmacological properties of PEA are discussed, in particular with respect to its analgesic and anti-inflammatory properties.

Keywords: Palmitoylethanolamide, anandamide, cannabinoid, N-acylethanolamines, dicyclohexylcarbodiimide, N-palmitoylethanolamine, N-oleoylethanolamine, Tetrahydrocannabinol, Amide Hydrolase

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Article Details

Page: [663 - 674]
Pages: 12
DOI: 10.2174/0929867023370707
Price: $58