Synthesis of Specific Protein Phosphatase Inhibitors, Tautomycin and Tautomycetin toward Structure-Activity Relationship Study

Author(s): H. Oikawa.

Journal Name: Current Medicinal Chemistry

Volume 9 , Issue 22 , 2002


The recent progress in synthetic and SAR studies of the specific protein phosphatase inhibitors tautomycin and tautomycetin is reviewed. This article covers the total synthesis of tautomycin and synthetic studies of the spiroketal and the anhydride segments and tautomycetin, and SAR studies on PP inhibition and apoptosis-inducing activity of tautomycin.

Keywords: Protein, Phosphatase Inhibitors, Tautomycin, Tautomycetin, apoptosis

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Article Details

Year: 2002
Page: [2033 - 2054]
Pages: 22
DOI: 10.2174/0929867023368818
Price: $58

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