Synthesis of Specific Protein Phosphatase Inhibitors, Tautomycin and Tautomycetin toward Structure-Activity Relationship Study

Author(s): H. Oikawa.

Journal Name: Current Medicinal Chemistry

Volume 9 , Issue 22 , 2002

Abstract:

The recent progress in synthetic and SAR studies of the specific protein phosphatase inhibitors tautomycin and tautomycetin is reviewed. This article covers the total synthesis of tautomycin and synthetic studies of the spiroketal and the anhydride segments and tautomycetin, and SAR studies on PP inhibition and apoptosis-inducing activity of tautomycin.

Keywords: Protein, Phosphatase Inhibitors, Tautomycin, Tautomycetin, apoptosis

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 9
ISSUE: 22
Year: 2002
Page: [2033 - 2054]
Pages: 22
DOI: 10.2174/0929867023368818
Price: $58

Article Metrics

PDF: 3