Abstract
Homeobox genes encode transcriptional regulators of embryonic development. Many genetic disorders affecting multiple organ systems have been associated with a diverse array of mutations in one or another of at least 27 different members of this gene family. We briefly describe the affected genes and the major phenotypes presented by the patients that carry the mutations. Although cause-and-effect relationships are difficult to prove in human genetics, there is little doubt that the observed mutations play a crucial role in the etiology of the associated disorders. The impressive wealth of collected data greatly benefits genetic counseling and stimulates efforts to develop novel avenues of targeted therapy
Keywords: Homeobox Genes, Human Genetic Disorders, Bicoid, Dlx3 gene, Emx2 gene, Hox genes, Lim-homeobox gene, Msx genes, Nkx2-5 gene, Paired homeobox genes
Current Molecular Medicine
Title: Homeobox Genes and Human Genetic Disorders
Volume: 2 Issue: 1
Author(s): Yangu Zhao and Heiner Westphal
Affiliation:
Keywords: Homeobox Genes, Human Genetic Disorders, Bicoid, Dlx3 gene, Emx2 gene, Hox genes, Lim-homeobox gene, Msx genes, Nkx2-5 gene, Paired homeobox genes
Abstract: Homeobox genes encode transcriptional regulators of embryonic development. Many genetic disorders affecting multiple organ systems have been associated with a diverse array of mutations in one or another of at least 27 different members of this gene family. We briefly describe the affected genes and the major phenotypes presented by the patients that carry the mutations. Although cause-and-effect relationships are difficult to prove in human genetics, there is little doubt that the observed mutations play a crucial role in the etiology of the associated disorders. The impressive wealth of collected data greatly benefits genetic counseling and stimulates efforts to develop novel avenues of targeted therapy
Export Options
About this article
Cite this article as:
Zhao Yangu and Westphal Heiner, Homeobox Genes and Human Genetic Disorders, Current Molecular Medicine 2002; 2 (1) . https://dx.doi.org/10.2174/1566524023363077
DOI https://dx.doi.org/10.2174/1566524023363077 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Evaluation of In Vivo and In Vitro Antimicrobial Activities of a Selective Serotonin Reuptake Inhibitor Sertraline Hydrochloride
Anti-Infective Agents Social Determinants, Race, and Brain Health Outcomes: Findings from the Chicago Health and Aging Project
Current Alzheimer Research Novel Nano Drug Systems for Cardiovascular Applications
Recent Patents on Biomedical Engineering (Discontinued) Smoking and Hypertension: Independent or Additive Effects to Determining Vascular Damage?
Current Vascular Pharmacology Oral Antidiabetic Agents: Anti-Atherosclerotic Properties Beyond Glucose Lowering?
Current Pharmaceutical Design Adverse Drug Reactions Amongst Adult Patients Admitted in Lagos State University Teaching Hospital Lagos, Nigeria
Current Drug Safety The Metabolism of Anthocyanins
Current Drug Metabolism Chemometric Modeling of 5-Phenylthiophenecarboxylic Acid Derivatives as Anti-Rheumatic Agents
Current Computer-Aided Drug Design Immunologic Considerations in Heart Transplantation for Congenital Heart Disease
Current Cardiology Reviews Sodium Intake Recommendations: A Subject that Needs to be Reconsidered
Current Hypertension Reviews Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females
Current Nutrition & Food Science Valsartan Protects Against Contrast-Induced Acute Kidney Injury in Rats by Inhibiting Endoplasmic Reticulum Stress-Induced Apoptosis
Current Vascular Pharmacology Genetic and Non-Genetic Determinants of the Pharmacological Activity of Statins
Current Drug Metabolism Recent Progress in Graphene Derivatives/Metal Oxides Binary Nanocomposites Based Chemi-resistive Sensors for Disease Diagnosis by Breath Analysis
Current Analytical Chemistry How Cardiomyocytes Make the Heart Old
Current Pharmaceutical Biotechnology Surgical Ventricular Restoration to Reverse Left Ventricular Remodeling
Current Cardiology Reviews Cardiac Applications for Human Pluripotent Stem Cells
Current Pharmaceutical Design Association between Antiretroviral Treatment and Markers of Systemic Inflammation among HIV Patients in Ghana
Current HIV Research PHB in Cardiovascular and Other Diseases: Present Knowledge and Implications
Current Drug Targets Antimicrobial Action of Chelating Agents: Repercussions on the Microorganism Development, Virulence and Pathogenesis
Current Medicinal Chemistry