Rationally Engineered Proteins or Antibodies with Absent or Reduced Immunogenicity

Author(s): S. Tangri, C. LiCalsi, J. Sidney, A. Sette.

Journal Name: Current Medicinal Chemistry

Volume 9 , Issue 24 , 2002

Abstract:

One challenge associated with the clinical use of protein therapeutics destined for chronic administration is the potential for the development of unwanted anti-drug immune reactions. The molecular basis for this reactivity is the binding of peptide fragments (epitopes) derived from the breakdown of the

Keywords: epitope, immunostealth, antibody, htl

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Article Details

VOLUME: 9
ISSUE: 24
Year: 2002
Page: [2191 - 2199]
Pages: 9
DOI: 10.2174/0929867023368647
Price: $58

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