Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
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The Therapeutic Potential of Host-Defense Antimicrobial Peptides

Author(s): N. Sitaram and R. Nagaraj

Affiliation: Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad - 500 007, India.

Abstract:

Species across the evolutionary scale from insects to mammals deploy peptides to counter microbial invaders. Although, there are considerable differences in the primary and secondary structures of these peptides, they exert their antimicrobial activity by common mechanisms ie. by membrane permeabilization. Extensive structure-function studies have been carried out on this class of antimicrobial peptides and ‘designer’ peptides have been generated which possess specific antimicrobial activity. In this article the physico-chemical properties and biological activities of host-defense peptides and ‘designer’ peptides would be reviewed with a view to explore whether they could be used as effective therapeutic agents.

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Article Details

VOLUME: 3
ISSUE: 3
Page: [259 - 267]
Pages: 9
DOI: 10.2174/1389450023347786
Price: $58